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pentobarbital will lessen the extent or result of isradipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.pentobarbital will lower the extent or outcome of fosaprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.fentanyl intranasal and pentobarbital both enhance sedation.